Healthcare-associated Gram-negative bloodstream infections: Antibiotic resistance and predictors of mortality

Autor: Emel Yilmaz, Serda Gulsun, Cigdem Ataman Hatipoglu, Ilkay Karaoglan, Fusun Can, Y. Tezer, Hikmet Eda Alışkan, Suda Tekin, Mehtap Aydin, Gulsen Yoruk, Şebnem Erdinç, Aynur Engin, H. Cabadak, Alpay Azap, Halis Akalin, Asuman Inan, Funda Şimşek, Hüseyin Bilgin, Aysegul Yesilkaya, Şafak Kaya, Lutfiye Mulazimoglu, Özlem Kurt Azap, Onder Ergonul, Funda Timurkaynak, Turhan Togan, Seniha Başaran, Serap Şimşek Yavuz, Ebru Kurşun
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı., Yılmaz, Emel, Akalın, Halis, AAU-8952-2020, [Ergonul, O. -- Tekin, S. -- Can, F.] Koc Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey -- [Aydin, M. -- Timurkaynak, F.] Baskent Univ, Sch Med, Istanbul Hosp, Infect Dis & Clin Microbiol Dept, Etimesgut Ankara, Turkey -- [Azap, A.] Ankara Univ, Fac Med, Infect Dis & Clin Microbiol Dept, TR-06100 Ankara, Turkey -- [Basaran, S. -- Yavuz, S. S.] Istanbul Univ, Istanbul Med Sch, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey -- [Kaya, S. -- Gulsun, S.] Diyarbakir Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Diyarbakir, Turkey -- [Yoruk, G.] Istanbul Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey -- [Kursun, E. -- Aliskan, H. E.] Baskent Univ, Sch Med, Adana Hosp, Infect Dis & Clin Microbiol Dept, Adana, Turkey -- [Yesilkaya, A. -- Azap, O.] Baskent Univ, Sch Med, Ankara Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey -- [Simsek, F.] Okmeydani Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey -- [Yilmaz, E. -- Akalin, H.] Uludag Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Bursa, Turkey -- [Bilgin, H. -- Mulazimoglu, L.] Marmara Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey -- [Hatipoglu, C. -- Erdinc, S.] Ankara Numune Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey -- [Cabadak, H. -- Tezer, Y.] Ankara Specialty Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey -- [Togan, T.] Baskent Univ, Sch Med, Konya Hosp, Infect Dis & Clin Microbiol Dept, Konya, Turkey -- [Karaoglan, I.] Gaziantep Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Gaziantep, Turkey -- [Inan, A.] Haydarpasa Numune Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Istanbul, Turkey -- [Engin, A.] Cumhuriyet Univ, Sch Med, Infect Dis & Clin Microbiol Dept, Sivas, Turkey
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Acinetobacter baumannii
Pediatrics
Turkey
Ventilator associated pneumonia
Klebsiella pneumoniae
Epidemiology
Healthcare associated infection
Antibiotic resistance
medicine.medical_treatment
Bacteremia
Bloodstream
Piperacillin plus tazobactam
Turkey (republic)
0302 clinical medicine
Controlled clinical trial
Prevalence
030212 general & internal medicine
Middle aged
Carbapenem
APACHE
Drug resistance
bacterial
Surveillance
Intensive care units
biology
Mortality rate
Antibiotic agent
Healthcare
Klebsiella-pneumoniae
General Medicine
Prognosis
Classification
Gram-negative
Multicenter study
Clinical trial
Retrospective study
Gram-negative bacteria
Pseudomonas aeruginosa
Infectious diseases
Female
lthInfectious diseases
Central venous catheter
Impactenterobacteriaceae
Human
Microbiology (medical)
Adult
medicine.medical_specialty
030106 microbiology
Gram-negative bacterial infections
Cephalosporin
Gram negative bacterium
Outcomes
Cause of death
Major clinical study
Bloodstream infection
Microbiology
Article
03 medical and health sciences
Cross infection
Intensive care
Internal medicine
Enterobacter cloacae
medicine
Escherichia coli
Humans
Intensive care unit
Mortality
Aged
Program
Drug effects
business.industry
Colistin
Quinoline derived antiinfective agent
Aminoglycoside antibiotic agent
Odds ratio
Survival analysis
medicine.disease
biology.organism_classification
Nonhuman
Beta-Lactamases
Carbapenem-Resistant Enterobacteriaceae
Klebsiella Pneumoniae
Confidence interval
Retrospective studies
Pneumonia
Risk factors
Isolation and purification
Gram negative infection
Risk factor
business
Controlled study
Public
environmental & occupational health
Popis: WOS: 000389233700014
PubMed ID: 27717604
This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age > 70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator- associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality. (C) 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
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