Investigating the relationship between plasma neuropeptide-S levels and clinical depression

Autor:	Ozgur Baykan, Onur Durmaz, Hayriye Baykan, Hayrettin Kara, Merve Şahin Can, Adnan Adil Hismiogullari, Tunay Karlidere
Rok vydání:	2018
Předmět:	Adult Male inorganic chemicals medicine.medical_specialty Central nervous system Neuropeptide 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders Neuropeptide S medicine Humans Endocrine system Psychiatry health care economics and organizations Depression (differential diagnoses) Depressive Disorder Major business.industry Neuropeptides technology industry and agriculture Middle Aged respiratory system 030227 psychiatry Psychiatry and Mental health Endocrinology medicine.anatomical_structure Anxiety Female medicine.symptom business 030217 neurology & neurosurgery
Zdroj:	Nordic Journal of Psychiatry. 72:292-295
ISSN:	1502-4725 0803-9488
DOI:	10.1080/08039488.2018.1444088
Popis:	Neuropeptide-S (NPS) is a novel 20-amino acid peptide, mainly expressed in the central nervous system and endocrine tissues. NPS has been linked to anxiety and fear-related behaviors. The association of NPS with depression in a human population has not been previously examined. The aim of the current study was to explore the potential association of NPS with clinical depression and comorbid anxiety.Seventy-nine patients diagnosed with major depressive disorder and seventy-eight controls were included in the study. The Hamilton Depression Scale (HAM-D) and Hamilton Anxiety Scale (HAM-A) were used to measure depression and anxiety levels, respectively. Venous blood samples were obtained to measure plasma NPS levels.There were no statistically significant differences between the patients and controls in terms of sex, marital status, and smoking status. Plasma NPS levels were also not significantly different between the patients and controls. In patients with major depressive disorder, HAM-A and HAM-D scores were significantly higher than those of controls. No correlation was found between plasma NPS levels and age, body mass index (BMI), median HAM-A scores, and median HAM-D scores.Despite a significantly high level of comorbid anxiety among the patient group, we found no relationship between plasma NPS levels and depressive symptomatology.
Databáze:	OpenAIRE
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