Impact of surveillance for Barrett's oesophagus on tumour stage and survival of patients with neoplastic progression
| Autor: | F, Kastelein, S H, van Olphen, E W, Steyerberg, M C W, Spaander, M J, Bruno, F, Lockefeer |
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| Přispěvatelé: | Gastroenterology & Hepatology, Pathology, Public Health |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms Population Adenocarcinoma Gastroenterology Barrett Esophagus 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Internal medicine Journal Article medicine Humans Prospective Studies Stage (cooking) Prospective cohort study education Survival analysis Aged Neoplasm Staging education.field_of_study business.industry Incidence (epidemiology) Middle Aged medicine.disease Survival Analysis Cancer registry Multicenter Study Early Diagnosis Dysplasia Population Surveillance 030220 oncology & carcinogenesis Disease Progression Female 030211 gastroenterology & hepatology Esophagoscopy business Precancerous Conditions |
| Zdroj: | Gut, 65(4), 548-554. BMJ Publishing Group Gut, 65(4), 548-54. BMJ PUBLISHING GROUP |
| ISSN: | 1468-3288 0017-5749 |
| Popis: | OBJECTIVE: Endoscopic surveillance for Barrett's oesophagus (BO) is under discussion given the overall low incidence of neoplastic progression and lack of evidence that it prevents advanced oesophageal adenocarcinoma (OAC). The aim of this study was to evaluate the impact of endoscopic BO surveillance on tumour stage and survival of patients with neoplastic progression.DESIGN: 783 patients with BO of at least 2 cm were included in a multicentre prospective cohort and followed during surveillance according to the American College of Gastroenterology guidelines. Cases of high-grade dysplasia and OAC were identified during follow-up. OAC staging was performed according to the 7th UICC-AJCC classification. Survival data were collected and crosschecked using death and municipal registries. Data from patients with OAC in the general population were obtained from the Dutch cancer registry. We compared survival of patients with BO with neoplastic progression during surveillance with those of patients without neoplastic progression and patients with OAC in the general population.RESULTS: 53 patients with BO developed high-grade dysplasia or OAC during surveillance. Thirty-five (66%) were classified as stage 0, 14 (26%) as stage 1 and 4 (8%) as stage 2. OAC was diagnosed at an earlier stage during BO surveillance than in the general population (pCONCLUSIONS: OAC is detected at an earlier stage during BO surveillance than in the general population with good survival rates. |
| Databáze: | OpenAIRE |
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