Soya protein does not affect glycaemic control in adults with type 2 diabetes
| Autor: | Alison M. Duncan, Johanna W. Lampe, Colleen P. Gobert, Elizabeth A. Pipe, Sarah E. Capes, Gerarda Darlington |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Glucose Male Glycosuria medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Type 2 diabetes Hysterectomy chemistry.chemical_compound Double-Blind Method Internal medicine Diabetes mellitus Insulin Secretion Humans Insulin Medicine Glycated Hemoglobin Cross-Over Studies Nutrition and Dietetics business.industry food and beverages Equol Middle Aged Isoflavones Milk Proteins Postprandial Period medicine.disease Crossover study Diet Records Postmenopause Endocrinology Postprandial Diabetes Mellitus Type 2 chemistry Sample Size Soybean Proteins Female medicine.symptom Energy Intake business |
| Zdroj: | British Journal of Nutrition. 103:412-421 |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | Evidence from observational, animal and human studies supports a role for soya protein and its isoflavones in the improvement of glycaemic control in type 2 diabetes. The objective of the present study was to determine the effect of isoflavone-rich soya protein on markers of glycaemic control in adults with type 2 diabetes. Using a randomised, crossover, double-blind, placebo-controlled design, adults with diet-controlled type 2 diabetes (n 29) consumed soya protein isolate (SPI) and milk protein isolate (MPI) for 57 d each separated by a 4-week washout. Blood was collected on days 1 and 57 of each treatment period for analysis of fasting HbA1C, and fasting and postprandial glucose, insulin and calculated indices of insulin sensitivity and resistance. Urine samples of 24 h were collected at the end of each treatment period for analysis of isoflavones. Urinary isoflavone excretion was significantly greater following consumption of SPI compared with MPI, and 20·7 % of the subjects (n 6) were classified as equol excretors. SPI consumption did not significantly affect fasting or postprandial glucose or insulin, fasting HbA1C, or indices of insulin sensitivity and resistance. These data do not support a role for soya protein in the improvement of glycaemic control in adults with diet-controlled type 2 diabetes and contribute to a limited literature of human studies on the effects of soya protein on the management of type 2 diabetes. |
| Databáze: | OpenAIRE |
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