Neutralization of TNF does not influence endotoxininduced changes in thyroid hormone metabolism in humans
| Autor: | S F Lowry, J M Agosti, S M Coyle, T van der Poll, Erik Endert |
|---|---|
| Přispěvatelé: | Other departments |
| Rok vydání: | 1999 |
| Předmět: |
Adult
Lipopolysaccharides Male medicine.medical_specialty Thyroid Hormones Lipopolysaccharide Triiodothyronine Reverse Physiology medicine.medical_treatment Recombinant Fusion Proteins Thyrotropin Receptors Tumor Necrosis Factor chemistry.chemical_compound Thyroid-stimulating hormone Physiology (medical) Internal medicine medicine Humans Receptor Triiodothyronine business.industry Tumor Necrosis Factor-alpha Thyroid Euthyroid Sick Syndromes Immunoglobulin Fc Fragments Endotoxins Thyroxine Endocrinology medicine.anatomical_structure Cytokine chemistry Immunoglobulin G Injections Intravenous Tumor necrosis factor alpha business Hormone |
| Zdroj: | American journal of physiology, 276(2 Part 2), R357-R362. American Physiological Society |
| ISSN: | 0002-9513 |
| Popis: | To determine the role of tumor necrosis factor (TNF) in endotoxin-induced changes in plasma thyroid hormone and thyroid-stimulating hormone (TSH) concentrations, 24 healthy postabsorptive humans were studied on a control study day ( n= 6), after infusion of a recombinant TNF receptor IgG fusion protein (TNFR:Fc; 6 mg/m2; n = 6) after intravenous injection of endotoxin (2 ng/kg; n = 6), or after administration of endotoxin with TNFR:Fc ( n = 6). Administration of TNFR:Fc alone did not affect thyroid hormone or TSH levels when compared with the control day. Endotoxin induced a transient rise in plasma TNF activity (1.5 h: 219 ± 42 pg/ml), which was completely prevented by TNFR:Fc ( P < 0.05). After endotoxin administration, plasmal-thyroxine (T4), free T4, 3,5,3′-triiodothyronine (T3), and TSH were lower and 3,3′,5′-triiodothyronine was higher than on the control day (all P < 0.05). Coinfusion of TNFR:Fc with endotoxin did not influence these endotoxin-induced changes. Our results suggest that endogenous TNF does not play an important role in the alterations in plasma thyroid hormone and TSH concentrations induced by mild endotoxemia in healthy humans. |
| Databáze: | OpenAIRE |
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