Dietary omega-3 polyunsaturated fatty acid intake is related to a protective high-density lipoprotein subspecies profile independent of genetic effects: A monozygotic twin pair study

Autor: Marianna Maranghi, Marja-Riitta Taskinen, Leonie H. Bogl, Kirsi H. Pietiläinen, Jaakko Kaprio, Aila Rissanen
Rok vydání: 2011
Předmět:
Male
Monozygotic twin
030204 cardiovascular system & hematology
Lipoprotein particle
Body Mass Index
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Finland
Adiposity
2. Zero hunger
chemistry.chemical_classification
Genetics
education.field_of_study
omega-3 fatty acids
Confounding
3-day food records
hdl subspecies
macronutrient composition
monozygotic twins
Electrophoresis
Polyacrylamide Gel
Female
lipids (amino acids
peptides
and proteins)
Lipoproteins
HDL
Cardiology and Cardiovascular Medicine
Polyunsaturated fatty acid
Adult
medicine.medical_specialty
Population
Nutritional Status
030209 endocrinology & metabolism
Biology
Nutrient density
Young Adult
03 medical and health sciences
Internal medicine
Fatty Acids
Omega-3
medicine
Humans
Particle Size
education
Twins
Monozygotic
Diet
Cross-Sectional Studies
Endocrinology
chemistry
Multivariate Analysis
Energy Intake
Lipoprotein
Zdroj: Atherosclerosis. 219:880-886
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2011.09.010
Popis: Background Studies on diet and high-density lipoprotein (HDL) subspecies distribution are limited. Objective We examined the relationship between macronutrient composition and lipoprotein particle size and HDL subspecies independent of genetic effects by studying monozygotic (MZ) twins. Methods 24 healthy MZ twin pairs aged 23–33 years were identified from two longitudinal population-based studies, FinnTwin16 and FinnTwin12. Total energy and nutrient intake were assessed with 3-day food records and physical activity was measured by the Baecke index. HDL subspecies distribution was determined by non-denaturing gradient gel electrophoresis. Associations between diet composition and HDL mean particle size were determined by multivariate nutrient density models adjusted for confounding variables. Results Substituting one energy percentage from omega-3 polyunsaturated fatty acids (n-3 PUFAs) for a corresponding amount of energy from other type of fats was related to changes in the relative proportions of the HDL subspecies 2b, 3a and 3b toward a larger mean particle size in men ( β ±SE: 1.00±0.26nm, p =0.004) and women ( β ±SE: 0.90±0.21nm, p =0.001). This association remained significant in analyses controlling for genetic and shared environmental influences using within-pair differences of the measures in MZ twin pairs ( β ±SE: 0.37±0.14nm, p =0.019). Twins with the higher n-3 PUFA intake had significantly higher proportions of large HDL 2b particles and lower proportions of smaller-sized HDL 3a and HDL 3b particles as compared to their co-twins with lower intakes ( p Conclusions Our data suggest that n-3 PUFA intake is associated with a favorable change in the distribution of HDL subspecies towards larger particles independent of genetic and shared environmental factors.
Databáze: OpenAIRE
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