DISPOSITION OF SULFADIMETHOXINE IN MALE LLAMAS (LLAMA GLAMA) AFTER SINGLE INTRAVENOUS AND ORAL ADMINISTRATIONS
| Autor: | Kathryn Junkins, James Jensen, Tanya Herzog, Jenifer Chatfield, Dawn M. Boothe |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Metabolic Clearance Rate Administration Oral Biological Availability Sulfadimethoxine Peak concentration Anti-Infective Agents Pharmacokinetics Oral administration Internal medicine medicine Animals Dosing Chromatography High Pressure Liquid Cross-Over Studies General Veterinary business.industry General Medicine Crossover study Pharmacokinetic analysis Bioavailability Endocrinology Area Under Curve Injections Intravenous Linear Models Animal Science and Zoology business Camelids New World Half-Life medicine.drug |
| Zdroj: | Journal of Zoo and Wildlife Medicine. 34:9-15 |
| ISSN: | 1042-7260 |
| DOI: | 10.1638/1042-7260(2003)34[0009:dosiml]2.0.co;2 |
| Popis: | This study determined the disposition of sulfadimethoxine in six, healthy, adult, gelded male llamas (Llama glama) by using a nonrandomized crossover design with i.v. dosing (58.8 +/- 3.0 mg/kg based on metabolic scaling) followed by oral dosing (59.3 mg/kg +/- 8.3). Blood samples were collected intermittently for a 72-hr period, and serum sulfadimethoxine concentrations were quantified using high-performance liquid chromatography. Serum sulfadimethoxine concentrations across time were subjected to standard pharmacokinetic analysis based on linear regression. Mean maximum serum concentration after oral dosing was 23.6 +/- 14.9 microg/ml, and extrapolated peak concentration after i.v. administration was 246.6 +/- 15.8 microg/ml. Total clearance of sulfadimethoxine was 45.4 +/- 13.9 L/kg. Half-lives after i.v. and oral administration were 541 +/- 111 min and 642.4 +/- 204.8 min, respectively. Oral bioavailability was 52.6 +/- 15%. These data suggest that the oral dose administered to llamas in this study, based on metabolic scaling from cattle, may be inadequate when compared with the reported minimum inhibitory concentration (512 microg/ml) breakpoint for sulfadimethoxine. |
| Databáze: | OpenAIRE |
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