Heating-induced contraction in airways smooth muscle: A possible causative factor of exercise-induced bronchoconstriction
| Autor: | Seham Mustafa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Contraction (grammar) Physiology Bronchoconstriction Isometric exercise Cholinergic Agonists In Vitro Techniques Heating 03 medical and health sciences 0302 clinical medicine Smooth muscle Heating temperature medicine Asthmatic patient Animals Respiratory system Human body temperature Sheep Chemistry Electromyography General Neuroscience Muscle Smooth respiratory system Cold Temperature Trachea 030228 respiratory system Biophysics Carbachol Female medicine.symptom 030217 neurology & neurosurgery Muscle Contraction |
| Zdroj: | Respiratory physiologyneurobiology. 259 |
| ISSN: | 1878-1519 |
| Popis: | Asthmatic patients often suffer from bronchoconstriction or asthma following breathing hot air or exposure to exercise due to raises the core body temperature. However, the direct effect of heating airways has not been studied yet. The aim of this study is to investigate the effect of heating on tracheal and bronchiolar smooth muscles. Isolated ovine tracheal strips and bronchiolar segments preparations were suspended in organ baths containing Krebs’ solution for isometric tension recording. Tissues responses were examined during decreasing and elevating baths temperature (20 °C, 40 °C–45 °C and 50 °C). Cooling or heating induced rapid and reproducible contractions proportional with decreasing or increasing temperature respectively in tracheal and bronchiolar preparations. On reset to 37 °C the tone returned rapidly to basal level. Changing the bath’s temperature from 37 °C to 20 °C or to 40 °C and 45 °C for tracheal strips or to 45 °C and 50 °C for bronchiolar segments induced contractions in both preparations. Changing the temperature below or above the normal body temperature (37 °C), leads to airways contractions. Heating induced contractions in tracheal and bronchiolar smooth muscle proportional to the heating temperature. Therefore, breathing hot air or elevation of body core temperature due to exercise can be considered possible causative factor of heating- or exercise-induced bronchoconstriction. |
| Databáze: | OpenAIRE |
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