Ozonation of valsartan: Structural elucidation and environmental properties of transformation products
| Autor: | Johannes Pinnekamp, Wilhelm Gebhardt, Miriam Diehle, Volker Linnemann, Andreas Schäffer |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Environmental Engineering
Health Toxicology and Mutagenesis 0208 environmental biotechnology 02 engineering and technology 010501 environmental sciences 01 natural sciences Organic compound Ozone medicine Environmental Chemistry Antihypertensive Agents 0105 earth and related environmental sciences chemistry.chemical_classification Chemistry Public Health Environmental and Occupational Health General Medicine General Chemistry Biodegradation Pollution 020801 environmental engineering Waste treatment Biodegradation Environmental Valsartan Wastewater Environmental chemistry Lipophilicity Sewage treatment Water treatment Water Pollutants Chemical medicine.drug |
| Zdroj: | Chemosphere. 216:437-448 |
| ISSN: | 0045-6535 |
| Popis: | The pharmaceutical valsartan is classified as a trace organic compound and is released into wastewater from human consumption. Trace organic compounds are not completely removed during conventional wastewater treatment. In order to prevent their release into the aquatic environment, advanced wastewater treatment technologies such as ozonation are currently implemented. Ozonation leads to the formation of transformation products (TPs), which then enter the receiving waters. In the present work, laboratory-scale ozonation experiments of valsartan solutions were performed. The resulting TPs were analyzed by HPLC-MS and searched for using a non-targeted approach. Of the 51 compounds detected, 27 have tentative structural suggestions based on MS/MS experiments. Ozonation of valsartan does not lead to the formation of TPs with higher toxicity towards A. fischeri than the parent compound. According to QSAR-based environmental behavior estimations, most TPs reveal lower lipophilicity, increased biodegradability as well as decreased acute and chronic toxicities concerning fish, daphnia and algae compared to their parent compound valsartan. |
| Databáze: | OpenAIRE |
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