Audit of practice in sudden unexpected death in epilepsy (SUDEP) post mortems and neuropathological findings
| Autor: | Sanjay M. Sisodiya, Timothy Dawson, Samden D. Lhatoo, Gabriella Wright, Beate Diehl, David A Hilton, Maria Thom, Josemir W. Sander, Matthias J. Koepp, Zuzanna Michalak, Abhijit Joshi |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Pediatrics Histology SUDEP Adolescent audit Audit Neuropathology Unexpected death Pathology and Forensic Medicine 03 medical and health sciences Epilepsy Death Sudden Young Adult 0302 clinical medicine Physiology (medical) medicine Humans Sampling (medicine) 030216 legal & forensic medicine Child post mortem Aged High rate Aged 80 and over neuropathology Medical Audit business.industry Original Articles Tissue sampling Middle Aged medicine.disease United Kingdom 3. Good health Neurology Child Preschool Original Article Sudden unexpected death in epilepsy Female Neurology (clinical) Autopsy Brain examination business 030217 neurology & neurosurgery |
| Zdroj: | Neuropathology and Applied Neurobiology |
| ISSN: | 1365-2990 0305-1846 |
| Popis: | Aims Sudden unexpected death in epilepsy (SUDEP) is one of the leading causes of death in people with epilepsy. For classification of definite SUDEP, a post mortem (PM), including anatomical and toxicological examination, is mandatory to exclude other causes of death. We audited PM practice as well as the value of brain examination in SUDEP. Methods We reviewed 145 PM reports in SUDEP cases from four UK neuropathology centres. Data were extracted for clinical epilepsy details, circumstances of death and neuropathological findings. Results Macroscopic brain abnormalities were identified in 52% of cases. Mild brain swelling was present in 28%, and microscopic pathologies relevant to cause or effect of seizures were seen in 89%. Examination based on whole fixed brains (76.6% of all PMs), and systematic regional sampling was associated with higher detection rates of underlying pathology (P |
| Databáze: | OpenAIRE |
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