Effect of metformin on global gene expression in liver of KKAy mice
| Autor: | Que-Ting Chen, Ji-Tao Teng, Xiao-Mei Song, Ting Liu, Zhi-Qin Liu, Kun Zhou, Du-Qiang Luo |
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| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty endocrine system diseases Peroxisome proliferator-activated receptor Pharmacology Mice 03 medical and health sciences Insulin resistance Diabetes mellitus Internal medicine Gene expression medicine Animals Hypoglycemic Agents chemistry.chemical_classification ATF6 business.industry Gene Expression Profiling nutritional and metabolic diseases General Medicine medicine.disease Metformin Mice Inbred C57BL Gene expression profiling 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Liver chemistry Signal transduction business medicine.drug |
| Zdroj: | Pharmacological Reports. 68:1332-1338 |
| ISSN: | 1734-1140 |
| Popis: | Background Metformin is a first-line drug for treating type 2 diabetes mellitus, yet its mechanism remains only partially understood and controversial. In this study we assessed a global gene expression profiling in liver of KKAy mice affected by metformin. This study aimed to identify the novel anti-diabetic mechanisms of metformin. Methods After KKAy mice were administered metformin for 5 weeks, the gene changes profile in the livers of KKAy mice were assessed by using the Agilent whole mice genome oligo microarray. Results Metformin altered the gene expression profiles in liver of KKAy mice. To our best knowledge, some genes have not been reported until now, such as Anxa2, Atf6, and so on. These genes were involved in many pathways, such as peroxisome proliferator activated receptor signaling pathway. Conclusions Gene expression changes induced by metformin were in support of the improvement of glucolipid metabolism and insulin resistance in KKAy mice. These findings expanded our knowledge of pharmacological action of metformin, and provided the potential novel insights and interesting information about the molecules involved in the antidiabetic effects of metformin. |
| Databáze: | OpenAIRE |
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