Ependymal enhancement on magnetic resonance imaging for the identification of high-grade gliomas
| Autor: | Muzna Iftikhar, Usman T. Siddiqui, Syed Ather Enam, Muhammad Waqas |
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| Rok vydání: | 2017 |
| Předmět: |
Population
White matter 03 medical and health sciences 0302 clinical medicine Positive predicative value Glioma Medicine education High-Grade Glioma education.field_of_study medicine.diagnostic_test business.industry Population mean Ependymal enhancement Magnetic resonance imaging medicine.disease Predictive value medicine.anatomical_structure 030220 oncology & carcinogenesis Surgery Neuro-Oncology: Original Article Neurology (clinical) business Nuclear medicine high-grade glioma 030217 neurology & neurosurgery tumor spread |
| Zdroj: | Surgical Neurology International |
| ISSN: | 2152-7806 |
| DOI: | 10.4103/sni.sni_77_17 |
| Popis: | Background High-grade gliomas have high infiltrative potential and spread along white matter and blood vessels. Enhancement of ependymal lining on magnetic resonance imaging (MRI) is considered as a marker of parenchymal spread of disease. In this study, we aimed to assess the sensitivity, specificity, and positive and negative predictive values of ependymal enhancement (EE) for identification of high-grade glial tumors. Methods We reviewed preoperative MRI scans of 94 consecutive patients surgically treated for space occupying lesions of the brain for EE. Assessment for EE was blind to the final histopathological diagnosis of the patient. An enhancement of more than 2 mm was considered positive. Pathologies of these patients were reviewed and matched to the radiological findings. Percentage and proportion of EE in glial and non-glial pathology groups was then calculated and a sensitivity and specificity analysis was performed. Results The population included 94 cases (64 males and 30 females) with population mean age 45 ± 15.5 years. Sensitivity of EE in differentiating glioma from total number of cases was 82.61% specificity 35.42% (P value = 0.048). EE had a sensitivity of 67.39% and specificity of 64.58% (P value = 0.002) in identifying high-grade glioma within the glioma group with a positive predictive value of 64.58% (95% CI: 49.46% to 77.83%), negative predictive value of 67.39% (95% CI: 51.98% to 80.46%). Conclusion EE has moderate sensitivity and specificity for high-grade gliomas. However, larger sample studies are required for further validation of this observations. |
| Databáze: | OpenAIRE |
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