A new theory on autoimmunity with reference to multiple sclerosis
| Autor: | Bjørn A. Nexø |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Multiple Sclerosis T-Lymphocytes Autoimmune diseases viruses Immunology Endogenous retrovirus Autoimmunity Biology medicine.disease_cause Multiple sclerosis 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Genetic Predisposition to Disease Endogenous retroviruses Chromosomes Human X Endogenous Retroviruses Models Immunological medicine.disease 030104 developmental biology Chromosomes Human Pair 19 030217 neurology & neurosurgery |
| Zdroj: | Nexø, B A 2018, ' A new theory on autoimmunity with reference to multiple sclerosis ', Immunologic Research, vol. 66, no. 3, pp. 336-339 . https://doi.org/10.1007/s12026-018-9003-x |
| ISSN: | 1559-0755 0257-277X |
| DOI: | 10.1007/s12026-018-9003-x |
| Popis: | Recent genetic evidence points towards endogenous retroviruses as playing a pivotal role in the causation of multiple sclerosis and possibly other autoimmune diseases. We discuss various ways in which this association could be brought about. Specifically, we suggest that two endogenous retroviruses, HERV-Fc1 and HERV-K13, on chromosomes X and 19, respectively, contribute to the development of autoimmune T cells by transforming them in multiple sclerosis. Partially overlapping sets of endogenous retroviruses may play a role in other autoimmune diseases. If this theory holds true, many scientists may have looked for viruses in the wrong tissue. Ir would also explain why lymphocyte-suppressive agents suppress multiple sclerosis. |
| Databáze: | OpenAIRE |
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