The Influence of Site of Collection on Postmortem Morphine Concentrations in Heroin Overdose Victims
| Autor: | Ross Zumwalt, Roberto L. Agüero Blau, Cameron S. Crandall, Patrick E. McKinney, B S Jonathon LaValley, Sarah Kerrigan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Narcotics Adolescent Femoral vein Femoral artery Drug overdose Gas Chromatography-Mass Spectrometry Pathology and Forensic Medicine Heroin medicine.artery Genetics medicine Humans Vein Forensic Pathology Blood Specimen Collection Morphine business.industry Heart Opioid overdose Femoral Vein Middle Aged medicine.disease Femoral Artery medicine.anatomical_structure Ventricle Postmortem Changes Anesthesia Linear Models Female Drug Overdose business medicine.drug |
| Zdroj: | Journal of Forensic Sciences. 51:413-420 |
| ISSN: | 1556-4029 0022-1198 |
| DOI: | 10.1111/j.1556-4029.2006.00067.x |
| Popis: | When assaying for postmortem morphine concentration, significant site sampling variability exists between central and peripheral sampling sites and even within sampling regions of the body. To study the variation, 76 suspected heroin overdoses were identified. Each had femoral artery (FA) and vein (FV), left and right ventricle and pooled heart blood samples obtained at autopsy. Forty-four tested positive for morphine. Morphine concentrations were determined by gas chromatography/mass spectrometry, with sampling site differences reported as log-transformed ratios and compared by signed rank test. The mean FA to FV ratio for total morphine was 1.2 (range 0-4.5). The ratio for left heart to right heart total morphine was 1.1 (range 0.4-3.2). Left ventricular to FV total morphine ratio was 2.0 (range 0.6-6.9). In these opioid overdose deaths, FA and FV morphine concentrations are usually similar, although up to 4.5-fold differences were noted. Centrally obtained morphine concentrations are on average twice as high compared with peripheral morphine concentrations. Left and right ventricular morphine concentrations were usually similar, although up to 3.2-fold differences were noted (left side higher). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text