The CALM and CALM/AF10 interactor CATS is a marker for proliferation
| Autor: | Christian Buske, Michael Hölzel, Thomas Harasim, Gerhard K. H. Przemeck, Sara Teresinha Olalla Saad, Aniruddha J. Deshpande, Dirk Eick, Stefan K. Bohlander, Philipp A. Greif, Martin Hrabé de Angelis, Elisabeth Kremmer, Leticia Fröhlich Archangelo |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
Oncogene Proteins Fusion Embryonic Development Biology Mice Genetics medicine Biomarkers Tumor Animals Humans RNA Neoplasm Nuclear protein Gene Cell Proliferation CATS Genes Essential Leukemia Cell growth Cell Cycle Intracellular Signaling Peptides and Proteins Nuclear Proteins General Medicine Cell cycle medicine.disease Hematopoietic Stem Cells Fusion protein Cell biology Neoplasm Proteins Haematopoiesis Cell Transformation Neoplastic Oncology Monomeric Clathrin Assembly Proteins Papers Cancer research Molecular Medicine Carrier Proteins |
| Popis: | The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis. |
| Databáze: | OpenAIRE |
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