Toward a postbiotic era of microbiome science: Opportunities to advance immunotherapies for hepatocellular carcinoma
| Autor: | Geicho Nakatsu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Carcinoma
Hepatocellular Hepatology business.industry Microbiota Liver Neoplasms Gastroenterology Tumor immunity medicine.disease digestive system diseases Immune checkpoint Blockade Hepatocellular carcinoma medicine Cancer research Humans Immunotherapy Microbiome Liver cancer business Immune Checkpoint Inhibitors Cancer immunology |
| Zdroj: | Journal of Gastroenterology and Hepatology. 37:34-38 |
| ISSN: | 1440-1746 0815-9319 |
| DOI: | 10.1111/jgh.15715 |
| Popis: | The microbiome has revolutionized the field of cancer immunology and checkpoint therapeutics for gastrointestinal malignancies. Combating hepatocellular carcinoma (HCC) by immune checkpoint blockade (ICB) is a unique challenge due in part to chronic complications that arise from local and systemic metabolic dysfunctions. Gut microbial metabolites modulate key immunological processes that influence liver cancer susceptibility and resistance to ICB. This review discusses recent progresses in linking microbiota functions to HCC tumor immunity and highlights their therapeutic potential. |
| Databáze: | OpenAIRE |
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