Effects of an androgenic steroid on exercise-induced cardiac remodeling in rats
| Autor: | M. Philippides, Angela J. Woodiwiss, B. Trifunovic, Gavin R. Norton |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.drug_class medicine.medical_treatment Heart Ventricles Diastole Physical exercise Internal dimension Ventricular Function Left Steroid Muscle hypertrophy Rats Sprague-Dawley Anabolic Agents Physiology (medical) Internal medicine Physical Conditioning Animal medicine Animals cardiovascular diseases Testosterone Congeners Ventricular Remodeling business.industry Heart Stroke Volume Organ Size Androgen Rats Endocrinology Circulatory system Collagen Wall thickness business |
| Zdroj: | Journal of applied physiology (Bethesda, Md. : 1985). 88(2) |
| ISSN: | 8750-7587 |
| Popis: | Habitual exercise results in a rightward shift in left ventricular end diastolic (LVED) pressure-volume or internal dimension (P-D) relationships [left ventricular (LV) remodeling]. However, exercise-mediated LV hypertrophy (LVH) produces an increased LV relative wall thickness [ratio ( h/ r) of wall thickness ( h) to internal radius ( r)] and hence a decrement in diastolic wall stress despite LV remodeling. In this study, the effect of chronic administration of an androgenic steroid on exercise-induced LV remodeling and h/ r was examined in rats. Habitual exercise on voluntary running wheels resulted in LVH and a rightward shift in the LVED P-D relationships. However, LVH was sufficient to increase LVED h/r. Androgenic steroid administration to exercised rats, without influencing the development of exercise-induced LVH, produced a further rightward shift in the LVED P-D relationship associated with an increased diameter intercept. As a consequence, LVED h/r was reduced to control values. The steroid-mediated effects were not associated with alterations in either the quantity or quality of LV collagen. In conclusion, high-dose androgenic steroid administration alters exercise-induced LV remodeling and subsequently reduces the beneficial effect of physiological LVH on LV h/ r. |
| Databáze: | OpenAIRE |
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