Diagnostic Evaluation of a High-Sensitivity Troponin I Point-of-Care Assay
| Autor: | Francisco Ojeda, Evangelos Giannitsis, Dirk Westermann, Eberhard Spanuth, Tanja Zeller, Stefan Blankenberg, Johannes T Neumann, Nils A Sörensen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Point-of-Care Systems Clinical Biochemistry Population Myocardial Infarction 030204 cardiovascular system & hematology Sensitivity and Specificity Cohort Studies 03 medical and health sciences 0302 clinical medicine Troponin T Risk Factors Troponin I medicine Humans Prospective Studies 030212 general & internal medicine Myocardial infarction Non-ST Elevated Myocardial Infarction education Prospective cohort study Aged Point of care education.field_of_study biology business.industry Biochemistry (medical) Emergency department Middle Aged medicine.disease Troponin Point-of-Care Testing Emergency medicine biology.protein Female Myocardial infarction diagnosis Emergency Service Hospital business Algorithms Biomarkers |
| Zdroj: | Clinical Chemistry. 65:1592-1601 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1373/clinchem.2019.307405 |
| Popis: | BACKGROUND Increasing numbers of patients are presenting worldwide to emergency departments with suspected myocardial infarction. The use of point-of-care troponin assays might enable faster decision-making in this high-risk population and reduce the burden on emergency facilities. Here, we evaluate the diagnostic performance of a point-of-care high-sensitivity troponin I assay. METHODS We conducted a prospective cohort study including patients presenting to the emergency department with suspected myocardial infarction from July 2013 to July 2016. A diagnostic algorithm for a high-sensitivity troponin I point-of-care assay was developed in a derivation data set with 669 patients and validated in an additional 610 patients. RESULTS The derived 0/1 h algorithm for the point-of-care assay consisted of an admission troponin I CONCLUSIONS The clinical application of a 0/1 h diagnostic algorithm based on a high-sensitivity troponin I point-of-care assay is safe, and diagnostic performance is comparable to a laboratory-based high-sensitivity troponin I assay. |
| Databáze: | OpenAIRE |
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