Associations between Self-Reported Daily Affect Ratings and Sleep Duration during the First Two Weeks of Antidepressant Therapy
| Autor: | Leslie M. Swanson, Holli Bertram, Giselle E. Kolenic, Ann Mooney, J. Todd Arnedt, Edward D. Huntley, Richard Dopp |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Neuroscience (miscellaneous) Medicine (miscellaneous) Context (language use) Affect (psychology) Article law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Humans Young adult Psychiatry Aged Depressive Disorder Major Fluoxetine business.industry Middle Aged medicine.disease Actigraphy Antidepressive Agents Antidepressant therapy 030228 respiratory system Major depressive disorder Female Self Report Neurology (clinical) Psychology (miscellaneous) Sleep business 030217 neurology & neurosurgery Sleep duration medicine.drug |
| Zdroj: | Behav Sleep Med |
| ISSN: | 1540-2010 1540-2002 |
| DOI: | 10.1080/15402002.2019.1695617 |
| Popis: | BACKGROUND: In the context of a randomized controlled trial evaluating the efficacy of augmenting fluoxetine treatment in young adults with major depressive disorder (MDD) using a modified repeated partial sleep deprivation protocol contrasting two weeks of restricted time in bed (i.e., 6h TIB) to no time in bed restriction (i.e., 8h TIB) the study examines whether sleep duration and the timing of repeated partial sleep deprivation predicts patient reported affect ratings. PARTICIPANTS: Participants included 58 young adults with DSM-IV-diagnosed MDD. METHODS: Daily ratings of affect and sleep were collected during the first two weeks of initiating fluoxetine treatment, yielding 630 person-days. Actigraphy monitoring was employed to assess compliance with time in bed condition. RESULTS: Negative affect ratings and positivity ratios in the morning were more improved among participants assigned to the 6h TIB condition compared to the 8h TIB group. Participants whose bedtime was delayed by 2 hours nightly demonstrated the most significant improvement in negative affect and positivity ratio during the first two weeks of fluoxetine therapy. Moreover, the trajectory of morning negative affect ratings in the first two weeks was predictive of remission after 4 weeks of fluoxetine therapy. CONCLUSIONS: These findings suggest that monitoring changes in daily affect may be a valuable marker of early treatment response in young adults with MDD. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01545843 |
| Databáze: | OpenAIRE |
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