A feasibility study for the non-invasive treatment of superficial bladder tumours with focused ultrasound
| Autor: | N A, Watkin, S B, Morris, I H, Rivens, C R, Woodhouse, G R, ter Haar |
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| Rok vydání: | 1996 |
| Předmět: |
Pathology
medicine.medical_specialty Bladder cancer Urinary bladder Swine business.industry Ultrasonic Therapy Urology Ultrasound Histology urologic and male genital diseases medicine.disease female genital diseases and pregnancy complications Extracorporeal medicine.anatomical_structure Urinary Bladder Neoplasms In vivo Cystitis Carcinoma medicine Animals Urothelium business |
| Zdroj: | BJU International. 78:715-721 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1046/j.1464-410x.1996.02189.x |
| Popis: | Objective To determine whether high-intensity focused ultrasound can be used to ablate bladder wall tissue using a transabdominal approach in a large animal model, and whether it can be developed as a non-invasive treatment for superficial bladder tumours. Materials and methods The bladder wall of 25 large white pigs was treated with a 1.7 MHz extracorporeal focused-bowl ultrasonic transducer. Animals were killed either 2 h, 3 days or 4 weeks after treatment and the bladder wall examined macroscopically and histologically. Results Acute bladder wall damage was detected in 15 of 16 animals at 2 h and in all six animals examined after 3 days. Areas of healing were seen in 10 of 12 animals at 4 weeks. Histological analysis of the treated areas revealed that the urothelium was denuded within 2 h and was associated with an acute inflammatory response in the bladder wall. At 4 weeks, the urothelium had regenerated over a maturing scar. Conclusions Focused ultrasound can be used successfully to destroy regions of the bladder wall in a large animal model in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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