Correlates of gallbladder stones among patients with sickle cell disease: A meta‐analysis

Autor: Almigdad H. M. Ali, Omer Ali Ibrahim, Sagad Omer Obeid Mohamed, Dahlia A A Mohammad
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
JGH Open, Vol 5, Iss 9, Pp 997-1003 (2021)
ISSN: 2397-9070
Popis: Sickle cell disorders are the most common hemoglobinopathies worldwide. Clinical variability of sickle cell disease (SCD) and susceptibility to its complications have been attributed to hematologic, genetic, and other influencing factors. This review aimed to provide further summary and analyses of the prevalence and factors associated with cholelithiasis among patients with SCD. A systematic database search was conducted in MEDLINE (PubMed), ScienceDirect, Google Scholar, World Health Organization Virtual Health Library, Cochrane Library databases, and System for Information on Gray Literature in Europe (SIGLE). Pooled prevalence, odds ratio (OR), and standardized mean difference (SMD) with the corresponding 95% confidence interval (CI) were calculated using Comprehensive Meta‐Analysis Software version 3.3. A total of 34 studies that fulfilled the eligibility criteria were included in the analyses. The overall prevalence of cholelithiasis among SCD patients was 25.3% (95% CI 19.4–32.3%). The risk of developing cholelithiasis was significantly associated with lower total hemoglobin level (SMD = −0.45; P = 0.002), lower hemoglobin F (HbF) level (SMD = −0.85; P = 0.003), higher total serum bilirubin level (SMD = 1.15; P
This meta‐analysis showed that up to a quarter of all sickle cell disease patients are susceptible to cholelithiasis. The risk of developing cholelithiasis is significantly associated with older age, lower total hemoglobin level, lower hemoglobin F level, higher total serum bilirubin level, higher reticulocytes count, and UDP‐glucuronosyltransferase‐1A1 enzyme (UGT1A1) promoter polymorphism.
Databáze: OpenAIRE
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