Thymus vulgaris L. Essential Oil Solid Formulation: Chemical Profile and Spasmolytic and Antimicrobial Effects

Autor: Roberta Budriesi, Gabriella Tocci, Rita Aldini, Alberto Chiarini, Carla Marzetti, Maria Frosini, Matteo Micucci, Michele Protti, Laura Mercolini, Ivan Corazza, Laura Beatrice Mattioli
Přispěvatelé: Micucci M., Protti M., Aldini R., Frosini M., Corazza I., Marzetti C., Mattioli L.B., Tocci G., Chiarini A., Mercolini L., Budriesi R.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Antifungal Agents
ved/biology.organism_classification_rank.species
Volatile
lcsh:QR1-502
Bifidobacterium breve
01 natural sciences
Biochemistry
lcsh:Microbiology
LC‐MS/MS
law.invention
chemistry.chemical_compound
Salmonella
law
Candida albicans
Carvacrol
Thymol
0303 health sciences
Molecular Structure
biology
L-type Calcium channels
LC-MS/MS
capillary electrochromatography
diarrhoea
intestinal contractility
solid based formulation
Animals
Anti-Bacterial Agents
Drug Compounding
Escherichia coli
Guinea Pigs
Lactobacillus fermentum
Microbial Sensitivity Tests
Muscle Contraction
Oils
Volatile
Parasympatholytics
Pseudomonas aeruginosa
Staphylococcus aureus
Streptococcus pyogenes
Thymus Plant
L‐type Calcium channels
Antimicrobial
L‐type Calcium channel
medicine.anatomical_structure
Thymus vulgaris
Ileum
Article
03 medical and health sciences
Capillary electrochromatography
Diarrhoea
Intestinal contractility
Solid based formulation
medicine
Molecular Biology
Essential oil
030304 developmental biology
Chromatography
010405 organic chemistry
ved/biology
biology.organism_classification
0104 chemical sciences
chemistry
Oils
Zdroj: Biomolecules, Vol 10, Iss 860, p 860 (2020)
Biomolecules
Volume 10
Issue 6
Popis: A new Thymus vulgaris L. solid essential oil (SEO) formulation composed of liquid EO linked to solid excipients has been chemically analysed and evaluated for its intestinal spasmolytic and antispastic effects in ex vivo ileum and colon of guinea pig and compared with liquid EO and excipients. Liquid EO and solid linked EO were analysed by original capillary electrochromatography coupled to diode array detection (CEC-DAD) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodologies. The main bioactive constituents are thymol and carvacrol, with minor constituents for a total of 12 selected analysed compounds. Liquid EO was the most effective in decreasing basal contractility in ileum and colon
excipients addiction permitted normal contractility pattern in solid linked EO SEO. In ileum and colon, the Thymus vulgaris L. solid formulation exerted the relaxant activity on K+-depolarized intestinal smooth muscle as well as liquid EO. The solid essential oil exhibits antimicrobial activity against different strains (Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Escherichia coli, Salmonella Thyphimurium, Candida albicans) similarly to liquid oil, with activity against pathogen, but not commensal strains (Bifidobacterium Breve, Lactobacillus Fermentum) in intestinal homeostasis. Therefore, Thymus vulgaris L. solid essential oil formulation can be proposed as a possible spasmolytic and antispastic tool in medicine.
Databáze: OpenAIRE
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