Histology and immunohistochemistry of fibrous posterior capsule opacification in an infant
| Autor: | Yuka Okada, Seiji Oda, Shizuya Saika, Yoshitaka Ohnishi, Kumi Shirai |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty genetic structures medicine.medical_treatment Lens Capsule Crystalline Intraocular lens Vimentin Cataract Extraction Cataract Extracellular matrix Postoperative Complications Lens Implantation Intraocular medicine Humans biology business.industry Capsule Infant Histology Epithelial Cells Anatomy Fibrosis Immunohistochemistry eye diseases Sensory Systems Actins Staining Fibronectins Ophthalmology medicine.anatomical_structure Lens (anatomy) biology.protein Surgery Female sense organs Collagen business |
| Zdroj: | Journal of cataract and refractive surgery. 30(2) |
| ISSN: | 0886-3350 |
| Popis: | We report the histological findings in posterior capsule opacification (PCO) in 2 eyes of a 10-month-old infant 8 months after cataract extraction and intraocular lens (IOL) implantation. The PCO in the right eye had a regenerated lenticular structure; in the left eye, it was fibrotic. The PCO in the right eye was soft and aspirated with Simcoe's irrigation/aspiration cannula; in the left eye, it was excised surgically. Paraffin sections of the fibrous PCO tissue from the left eye were examined histologically. Hematoxylin-eosin staining showed extracellular matrix (ECM) accumulation and the presence of elongated fibroblastic cells, presumed to be lens epithelial cells (LECs). Immunohistochemistry revealed the presence of fibrous collagen types and cellular fibronectin. The presumed LECs amid the ECM were positive for vimentin and alpha-smooth muscle actin. Histology of the fibrous PCO tissue from this infant was similar to that in adult patients. |
| Databáze: | OpenAIRE |
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