Resistant carbohydrates stimulate cell proliferation and crypt fission in wild-type mice and in theApcMin/+mouse model of intestinal cancer, association with enhanced polyp development
| Autor: | Hans N. Englyst, Robert A. Goodlad, N Mandir |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Dietary Fiber
medicine.medical_specialty Genes APC Colon Ratón Adenomatous polyposis coli Crypt Medicine (miscellaneous) Gastroenterology Mice Internal medicine Intestine Small medicine Animals Gastrointestinal cancer Intestinal Mucosa Intestinal Cancer Cell Proliferation Nutrition and Dietetics biology Cell growth Intestinal Polyps Organ Size medicine.disease Molecular biology Mice Mutant Strains Epithelium Small intestine Mice Inbred C57BL medicine.anatomical_structure Adenomatous Polyposis Coli Malus Fermentation Models Animal biology.protein Female Spleen |
| Zdroj: | British Journal of Nutrition. 100:711-721 |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | Fermentation of carbohydrates in the colon can stimulate cell proliferation and could thus be a cancer risk. The effects of resistant carbohydrates, i.e. those not digested and absorbed in the small intestine, on cell proliferation, crypt fission and polyp development were investigated in wild-type and adenomatous polyposis coli multiple intestinal neoplasia (ApcMin/+) mice. Fifteen 4-week-old female wild-type and fifteenApcMin/+mice were used for each group and fed a chow diet, a semi-synthetic diet or the semi-synthetic supplemented with wheat bran or an apple pomace preparation, both high in resistant carbohydrates, for 8 weeks. Tissue from all mice was used to measure cell proliferation and crypt fission and tissue from theApcMin/+mice was scored for polyp number and tumour burden. There were slight reductions in intestinal mass in the mice fed the semi-synthetic diets and this was increased by the inclusion of resistant carbohydrates. TheApcMin/+mice had elevated cell proliferation and crypt fission in the distal small intestine and colon and these were increased by the resistant carbohydrates. Bran or apple pomace significantly increased polyp number in the proximal third of the small intestine. Apple pulp more than doubled polyp number throughout the small bowel (99·2 (sem11·1)v.40·0 (sem8·2),P P |
| Databáze: | OpenAIRE |
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