Aging, COPD, and Other Risk Factors Do Not Explain the Increased Prevalence of Pulmonary Mycobacterium avium Complex in Ontario
| Autor: | Frances Jamieson, Kevin May, Pamela Chedore, Theodore K. Marras, Mohammed Al-Houqani, Mauli Mehta |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Aging medicine.medical_specialty Population Prevalence Disease Critical Care and Intensive Care Medicine Pulmonary Disease Chronic Obstructive Age Distribution Risk Factors Internal medicine medicine Humans Risk factor education Pathogen Aged Mycobacterium avium-intracellulare Infection Retrospective Studies Aged 80 and over Ontario education.field_of_study COPD Lung business.industry Age Factors Retrospective cohort study Middle Aged Mycobacterium avium Complex medicine.disease medicine.anatomical_structure Immunology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Chest. 141:190-197 |
| ISSN: | 0012-3692 |
| Popis: | Background The cause of observed increases in pulmonary Mycobacterium avium complex (pMAC) isolation and disease is unexplained. To explore possible causes of the increase in pMAC isolation and disease prevalence in Ontario, Canada, we studied age and other population-level risk factors. Methods We determined age and sex of patients with pMAC disease between 2003 and 2008. We then estimated whether the potential effect of population aging and changes in prevalence of HIV infection, solid organ transplant, COPD, and tumor necrosis factor-α (TNF-α) inhibition have contributed to the observed increase in pMAC disease. Results During 2003 to 2008, pMAC isolation and disease prevalence (per 100,000) both increased (8.44 to 12.62 and 4.35 to 6.81, respectively). The total number of cases of disease increased by 348 (2.46 per 100,000). Based on actual contemporary population changes, aging could explain 70 additional cases (increase of 0.57 per 100,000). The increase in self-reported COPD prevalence could potentially explain 11 (95% CI, 0-42) additional cases (increase of 0.09 per 100,000 [95% CI, 0-0.34 per 100,000]). HIV infection, solid organ transplant, and TNF-α inhibition combined could potentially explain no more than 73 additional cases (increase of 0.60 per 100,000). Conclusions Although population aging appears to be a major risk factor, the increase in pMAC disease in Ontario could be only partly explained by aging, increases in COPD, HIV, solid organ transplantation, and TNF-α inhibition therapy. The increase in pMAC is likely multifactorial and may be affected by environmental or pathogen factors not addressed in this study. |
| Databáze: | OpenAIRE |
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