Autor: |
Luk, CW, Lee, V, Leung, Y, Ng, MHL, Mejstrikova, E, Hrusak, O, Ling, SC, Li, CH, Lee, ACW, Cheuk, KLD, Ha, SY, Leung, AWK, Shing, MMK, Cheng, CK, Ip, RKL, Chan, NPH, Li, CK, Lau, KM, Cheng, SH |
Jazyk: |
angličtina |
Rok vydání: |
2013 |
Předmět: |
|
Zdroj: |
PLoS ONE, Vol 8, Iss 7, p e69467 (2013) PLoS ONE |
ISSN: |
1932-6203 |
Popis: |
Minimal residual disease, or MRD, is an important prognostic indicator in childhood acute lymphoblastic leukemia. In ALL-IC-BFM 2002 study, we employed a standardized method of flow cytometry MRD monitoring for multiple centers internationally using uniformed gating, and determined the relevant MRD-based risk stratification strategies in our local patient cohort. We also evaluated a novel method of PCR MRD quantitation using peripheral blood plasma. For the bone marrow flow MRD study, patients could be stratified into 3 risk groups according to MRD level using a single time-point at day-15 (Model I) (I-A: 10%), or using two time-points at day-15 and day-33 (Model II) (II-A: day-15 |
Databáze: |
OpenAIRE |
Externí odkaz: |
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