Cyperus esculentusL. (tigernut) mitigates high salt diet‐associated testicular toxicity in Wistar rats by targeting testicular steroidogenesis, oxidative stress and inflammation
| Autor: | Peace Okon Owai, Faith Nuhu Madaki, Inah Onete Inah, Stephanie Chinelo Iheduru, Joy Agede Ogar, Nichole Edikan Okorie, Ernest Atelhe Amama, Justina Nwandimma Nwangwa, Augustine L. Udefa, Hamza Joseph Ibrahim, Elayofa Victory Karawei |
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| Rok vydání: | 2020 |
| Předmět: |
Male
endocrine system medicine.medical_specialty animal structures Urology 030232 urology & nephrology Inflammation Sodium Chloride medicine.disease_cause Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Downregulation and upregulation Internal medicine Testis medicine Animals Testosterone Cyperus Rats Wistar 030219 obstetrics & reproductive medicine General Medicine Malondialdehyde Sertoli cell Sperm Diet Rats Oxidative Stress medicine.anatomical_structure chemistry medicine.symptom Oxidative stress Hormone |
| Zdroj: | Andrologia. 52 |
| ISSN: | 1439-0272 0303-4569 |
| Popis: | High salt diet (HSD) impairs testicular function via oxidative stress. Cyperus esculentus contains antioxidants and improves testicular function. We investigated the protective effect of hydro-ethanolic extract of Cyperus esculentus on testicular function in HSD-fed Wistar rats. Twenty-five male Wistar rats (125-135 g) 8-9 weeks old were divided into five groups (n = 5): control, HSD-fed (8 % NaCl in feed), extract-treated (500 mg kg-1 day-1 ), HSD-fed +500 mg kg-1 day-1 of extract and HSD-fed +1,000 mg kg-1 day-1 of extract groups. Treatment lasted for 6 weeks. HSD decreased (p |
| Databáze: | OpenAIRE |
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