Behaviorally conditioned immunosuppression in the rat is regulated via noradrenaline and β-adrenoceptors
| Autor: | Volker Limmroth, Stilla Frede, Yufen Xie, Marion U. Goebel, Bettina A. Meier, Martin Mosen, Michael S. Exton, Manfred Schedlowski, Claudia Gierse |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Agonist medicine.medical_specialty Sympathetic nervous system Adrenergic receptor Neuroimmunomodulation medicine.drug_class medicine.medical_treatment Adrenergic beta-Antagonists Immunology Propranolol Interferon-gamma Norepinephrine Internal medicine Cyclosporin a Receptors Adrenergic beta medicine Splenocyte Animals Immunology and Allergy RNA Messenger Oxidopamine Cells Cultured Immunosuppression Therapy Behavior Animal Chemistry Sympathectomy Chemical Antagonist Adrenergic beta-Agonists Rats Cytokine medicine.anatomical_structure Endocrinology Neurology Sympatholytics Interleukin-2 Neurology (clinical) Cell Division Spleen medicine.drug |
| Zdroj: | Journal of Neuroimmunology. 131:21-30 |
| ISSN: | 0165-5728 |
| Popis: | Using Cyclosporin A (CsA) as an unconditioned stimulus has previously demonstrated that behaviorally conditioned inhibition of splenocyte proliferation and cytokine production is mediated via the splenic nerve. Therefore, we currently examined the adrenergic modulation of conditioned suppression of splenocyte function. Chemical sympathectomy via 6-OHDA completely blocked the conditioned suppression of splenocyte proliferation to mitogens and cytokine (IL-2, IFN-gamma) production. Furthermore, administration of beta-adrenoceptor antagonist propranolol abrogated the conditioned effect on splenocyte proliferation. Supporting the position that conditioning is beta-adrenergic-dependent, addition of beta-adrenoceptor agonist, but not alpha-adrenoceptor agonists, to splenocytes in vitro mimicked the conditioned suppression of splenocyte functions, with these effects blocked by propranolol. Therefore, these data indicate that behavioral conditioning of splenocyte function in the rat is regulated by the sympathetic nervous system, predominantly via beta-adrenergic mechanisms. |
| Databáze: | OpenAIRE |
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