Scores Obtained from a Simple Cognitive Test of Visuospatial Episodic Memory Performed Decades before Death Are Associated with the Ultimate Presence of Alzheimer Disease Pathology
| Autor: | Neil Pendleton, Yvonne S Davidson, Lynn McInnes, David M. A. Mann, Julie S. Snowden, Andrew C Robinson, Michael A. Horan, Roseanne McNamee |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Longitudinal study Pathology medicine.medical_specialty Genotype Cognitive Neuroscience Memory Episodic Population Disease Neuropathology Neuropsychological Tests 03 medical and health sciences 0302 clinical medicine Apolipoproteins E Cognition Alzheimer Disease Journal Article Medicine Humans Longitudinal Studies education Aged Aged 80 and over education.field_of_study business.industry Neuropsychology Age Factors Brain medicine.disease Immunohistochemistry Cognitive test C800 B900 Psychiatry and Mental health 030104 developmental biology Female Geriatrics and Gerontology Alzheimer's disease business 030217 neurology & neurosurgery |
| Zdroj: | Robinson, A C, McNamee, R, Davidson, Y S, Horan, M A, Snowden, J S, McInnes, L, Pendleton, N & Mann, D M A 2018, ' Scores Obtained from a Simple Cognitive Test of Visuospatial Episodic Memory Performed Decades before Death Are Associated with the Ultimate Presence of Alzheimer Disease Pathology ', Dementia and Geriatric Cognitive Disorders, vol. 45, no. 1-2, pp. 79-90 . https://doi.org/10.1159/000486827 |
| ISSN: | 1421-9824 1420-8008 |
| Popis: | Background: Community- or population-based longitudinal studies of cognitive ability with a brain donation end point offer an opportunity to examine relationships between pathology and cognitive state prior to death. Discriminating the earliest signs of dementing disorders, such as Alzheimer disease (AD), is necessary to undertake early interventions and treatments. Methods: The neuropathological profile of brains donated from The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age, including CERAD (Consortium to Establish a Registry for Alzheimer’s Disease) and Braak stage, was assessed by immunohistochemistry. Cognitive test scores collected 20 years prior to death were correlated with the extent of AD pathology present at death. Results: Baseline scores from the Memory Circle test had the ability to distinguish between individuals who developed substantial AD pathology and those with no, or low, AD pathology. Predicted test scores at the age of 65 years also discriminated between these pathology groups. The addition of APOE genotype further improved the discriminatory ability of the model. Conclusions: The results raise the possibility of identifying individuals at future risk of the neuropathological changes associated with AD over 20 years before death using a simple cognitive test. This work may facilitate early interventions, therapeutics and treatments for AD by identifying at-risk and minimally affected (in pathological terms) individuals. |
| Databáze: | OpenAIRE |
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