Communiferulins, farnesylated coumarins from the roots of Ferula communis and their anti-neuroinflammatory activity

Autor: Yuki Yoshino, Naonobu Tanaka, Daisuke Tsuji, Kohji Itoh, Yoshiki Kashiwada
Rok vydání: 2022
Předmět:
Zdroj: Journal of Natural Medicines. 77:173-179
ISSN: 1861-0293
1340-3443
DOI: 10.1007/s11418-022-01657-8
Popis: Three new farnesylated coumarins, communiferulins A-C (1-3), and a farnesylated chromone, ferchromone (4), were isolated from the roots of an Apiaceous plant Ferula communis. Their structures including the relative configurations were elucidated by a combination of spectroscopic analyses and calculations of the NMR data. Communiferulins A-C (1-3) had dihydrofuran rings fused to C-3 and C-4 of their coumarin moieties, while 3 possessed one additional furan ring. HPLC analyses using a chiral column showed 1-4 to be racemates, and the absolute configurations of (+)-1, (-)-1, (+)-2, and (-)-2 were deduced by comparison of their ECD spectra with TDDFT-calculated spectra. Communiferulins A (1) and B (2), and ferchromone (4) showed inhibitory activities on IL-1β production from LPS-stimulated microglial cells.
Databáze: OpenAIRE
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