835. Inhibition of Hepatic SPARC (Secreted Protein Acidic and Rich in Cysteine) Expression for the Treatment of Experimental Cirrhosis

Autor:	Marcelo Silva, Guillermo Mazzolini, Alejandra M. Camino, Osvaldo L. Podhajcer, Federico Prada
Rok vydání:	2006
Předmět:	Pharmacology chemistry.chemical_classification Biology Biochemistry chemistry Drug Discovery otorhinolaryngologic diseases Genetics Hepatic stellate cell Molecular Medicine sense organs Cell adhesion Glycoprotein Molecular Biology Experimental cirrhosis Cysteine
Zdroj:	Molecular Therapy. 13:S322-S323
ISSN:	1525-0016
DOI:	10.1016/j.ymthe.2006.08.921
Popis:	Introduction: SPARC is a 42-kDa matricellular glycoprotein involved in many biological process including cell adhesion, differentiation and proliferation. SPARC is also expressed by activated hepatic stellate cells suggesting its involvement in liver fibrogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022c1b8e4b9214e113f180f8d5a94861 https://doi.org/10.1016/j.ymthe.2006.08.921 Zobrazit plný text záznamu