Episodic Memory and Hippocampal Volume Predict 5-Year Mild Cognitive Impairment Conversion in Healthy Apolipoprotein ε4 Carriers
| Autor: | Margaret Abraham, Stephen M. Rao, Dana A. Kelly, Kristy A. Nielson, John L. Woodard, J. Carson Smith, Michael Seidenberg, Sally Durgerian |
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| Rok vydání: | 2020 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty Heterozygote Memory Episodic Apolipoprotein E4 Hippocampus Audiology Neuropsychological Tests Logistic regression behavioral disciplines and activities Article Risk Factors mental disorders medicine Dementia Humans Cognitive Dysfunction Cognitive impairment Episodic memory Aged Aged 80 and over business.industry General Neuroscience Cognition medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology Female Neurology (clinical) Alzheimer's disease Atrophy business |
| Zdroj: | J Int Neuropsychol Soc |
| ISSN: | 1469-7661 1355-6177 |
| Popis: | Objective:The Apolipoprotein (APOE) ε4 allele increases the risk for mild cognitive impairment (MCI) and dementia, but not all carriers develop MCI/dementia. The purpose of this exploratory study was to determine if early and subtle preclinical signs of cognitive dysfunction and medial temporal lobe atrophy are observed in cognitively intact ε4 carriers who subsequently develop MCI.Methods:Twenty-nine healthy, cognitively intact ε4 carriers (ε3/ε4 heterozygotes; ages 65–85) underwent neuropsychological testing and MRI-based measurements of medial temporal volumes over a 5-year follow-up interval; data were converted toz-scores based on a non-carrier group consisting of 17 ε3/ε3 homozygotes.Results:At follow-up, 11 ε4 carriers (38%) converted to a diagnosis of MCI. At study entry, the MCI converters had significantly lower scores on the Mini-Mental State Examination, Rey Auditory Verbal Learning Test (RAVLT) Trials 1–5, and RAVLT Immediate Recall compared to non-converters. MCI converters also had smaller MRI volumes in the left subiculum than non-converters. Follow-up logistic regressions revealed that left subiculum volumes and RAVLT Trials 1–5 scores were significant predictors of MCI conversion.Conclusions:Results from this exploratory study suggest that ε4 carriers who convert to MCI exhibit subtle cognitive and volumetric differences years prior to diagnosis. |
| Databáze: | OpenAIRE |
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