Identification and expression of iron regulators in human synovium: evidence for upregulation in haemophilic arthropathy compared to rheumatoid arthritis, osteoarthritis, and healthy controls

Autor:	B. S. Van Asbeck, Roger E. G. Schutgens, K. van Veghel, Floris P J G Lafeber, Goris Roosendaal, M. J. G. Wenting, Douwe H. Biesma, Laurens Nieuwenhuizen
Rok vydání:	2013
Předmět:	Iron Ferroportin Arthritis Osteoarthritis Hemophilia A Arthritis Rheumatoid Mice Hepcidin Synovitis Hemarthrosis medicine Animals Humans Genetics (clinical) biology business.industry Synovial Membrane Iron-Regulatory Proteins Hematology General Medicine medicine.disease Up-Regulation Disease Models Animal Heme carrier protein 1 medicine.anatomical_structure Rheumatoid arthritis Case-Control Studies Immunology biology.protein Synovial membrane business
Zdroj:	Haemophilia : the official journal of the World Federation of Hemophilia. 19(4)
ISSN:	1365-2516
Popis:	Recurrent joint bleeding is the most common manifestation of severe haemophilia resulting in haemophilic arthropathy (HA). Iron plays a central role in the pathogenesis of the two main features of HA: synovitis and cartilage destruction. The aim of this study was to investigate the synovial presence of the iron regulator proteins ferroportin (FPN), hepcidin, haemoglobin scavenger receptor CD163 (CD163), feline leukaemia virus subgroup C (FLVCR), and heme carrier protein 1 (HCP-1). A comparison of the expression in HA with rheumatoid arthritis (RA), osteoarthritis (OA), and healthy controls (HC) is made. Synovial expression of iron regulators was investigated by immunohistochemistry in human synovial tissue and in a murine haemophilia model. We demonstrate for the first time the synovial presence of the investigated iron regulator proteins. Expression of the iron regulator proteins FPN, CD163, FLVCR, and HCP-1 was enhanced in HA in comparison to RA, OA, and HC synovium. In addition, in a murine haemophilia model of acute joint bleeding, synovial expression of FPN, CD163, and HCP-1 was increased. In both human and murine experiment, synovial expression of hepcidin was not altered. These findings indicate the presence of iron regulator proteins in the synovium, demonstrate an enhanced expression of FPN, CD163, FLVCR, and HCP-1 in HA, and suggest a synovial adaptation mechanism to maintain synovial iron homeostasis in HA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022a2552a459bc50966b52d4fa9e45e3 https://pubmed.ncbi.nlm.nih.gov/23777533 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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