Immune System Remodelling by Prenatal Betamethasone : Effects on β-Cells and Type 1 Diabetes
| Autor: | Marta Vives-Pi, Eva Tolosa, David Perna-Barrull, Silvia Rodriguez-Fernandez, Anna Gieras |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Future studies Unknown aetiology Endocrinology Diabetes and Metabolism Mini Review Anti-Inflammatory Agents β cell 030209 endocrinology & metabolism Bioinformatics Betamethasone lcsh:Diseases of the endocrine glands. Clinical endocrinology Β cell 03 medical and health sciences 0302 clinical medicine Immune system Fetus Endocrinology Glucocorticoid Pregnancy Insulin-Secreting Cells medicine Humans Type 1 diabetes lcsh:RC648-665 business.industry Multifactorial disease Prenatal betamethasone medicine.disease immune system 030104 developmental biology Diabetes Mellitus Type 1 prenatal betamethasone Female glucocorticoid business medicine.drug |
| Zdroj: | Frontiers in Endocrinology, Vol 11 (2020) Frontiers in Endocrinology |
| Popis: | Type 1 diabetes (T1D) is a multifactorial disease of unknown aetiology. Studies focusing on environment-related prenatal changes, which might have an influence on the development of T1D, are still missing. Drugs, such as betamethasone, are used during this critical period without exploring possible effects later in life. Betamethasone can interact with the development and function of the two main players in T1D, the immune system and the pancreatic β-cells. Short-term or persistent changes in any of these two players may influence the initiation of the autoimmune reaction against β-cells. In this review, we focus on the ability of betamethasone to induce alterations in the immune system, impairing the recognition of autoantigens. At the same time, betamethasone affects β-cell gene expression and apoptosis rate, reducing the danger signals that will attract unwanted attention from the immune system. These effects may synergise to hinder the autoimmune attack. In this review, we compile scattered evidence to provide a better understanding of the basic relationship between betamethasone and T1D, laying the foundation for future studies on human cohorts that will help to fully grasp the role of betamethasone in the development of T1D. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|