Significant Relationship of Matrix Metalloproteinase 9 with Nuclear Grade and Prognostic Impact of Tissue Inhibitor of Metalloproteinase 2 for Incidental Clear Cell Renal Cell Carcinoma
| Autor: | Yasuhiro Okada, Yusuke Nagane, Taketo Ichinose, Kenya Yamaguchi, Nozomu Kawata, Hitoshi Hirakata, Satoru Takahashi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Nephrology Pathology medicine.medical_specialty Urology Matrix metalloproteinase Gastroenterology Renal cell carcinoma Internal medicine Biomarkers Tumor Matrix Metalloproteinase 14 medicine Humans Carcinoma Renal Cell Aged Aged 80 and over Tissue Inhibitor of Metalloproteinase-2 Univariate analysis Tissue Inhibitor of Metalloproteinase-1 business.industry Middle Aged Tissue inhibitor of metalloproteinase Prognosis medicine.disease Immunohistochemistry Kidney Neoplasms Clear cell renal cell carcinoma Matrix Metalloproteinase 9 Clear cell carcinoma Matrix Metalloproteinase 2 Female business Kidney cancer |
| Zdroj: | Urology. 69:1049-1053 |
| ISSN: | 0090-4295 |
| Popis: | OBJECTIVE To examine the immunoreactivity of tumors for matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1, TIMP-2), and membrane type MMP 1 (MT-MMP-1), to evaluate the optimum assessment of incidental renal cell carcinoma. METHODS Tumor samples from 120 incidental clear cell renal cell carcinoma (ICRCC) patients without distant metastasis or invasion beyond Gerota's fascia were obtained by surgery. They were immunohistochemically stained for MMP-2, MMP-9, TIMP-1, TIMP-2, and MT-MMP-1. Immunoreactivity for these factors was analyzed by semiquantitative multivariate analysis for cancer-specific survival. RESULTS The cancer-specific 5 and 10-year survival rates were 91.4% and 91.4%, respectively. Univariate analysis revealed that nuclear grade (P = 0.0064) and TIMP-2 (P = 0.034) were significant prognostic factors. Matrix metalloproteinase 9 has a significant relationship with high nuclear grade RCC (P = 0.017) and was found to be an independent prognosticator by Cox multiple regression analysis (P = 0.0028). CONCLUSIONS Nuclear grade and TIMP-2 were significant prognostic factors of ICRCC. Multivariate analysis showed that a nuclear grade greater than 3 was associated with a 566% significant increase in the odds of cancer death. Strong expression of MMP-9 was associated with a 774% increase in the odds of high nuclear grade, with statistical significance. Although ICRCC is well known for having a favorable prognosis, patients with tumors having a high nuclear grade and strongly expressed MMP-9 and TIMP-2 should undergo strict postoperative follow-up. |
| Databáze: | OpenAIRE |
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