An in vivo study of the pharmacological activities of a methanolic acetate fraction of Pistia stratiotes L.: An ethno-medicinal plant used in Bangladesh
| Autor: | Md. Murad Hasan, Md. Ibrahim, Suzia Akter Suchi, Md. Giash Uddin, Mohammad Tarek Aziz, Md. Saddam Hussain |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.drug_class
Analgesic 01 natural sciences Open field Anti-inflammatory 03 medical and health sciences Acetic acid chemistry.chemical_compound P. stratiotes 0302 clinical medicine medicine Pistia Stratiotes Traditional medicine biology Chemistry Original Articles General Medicine analgesic biology.organism_classification formalin 0104 chemical sciences 010404 medicinal & biomolecular chemistry acetic acid CNS‐depressant 030220 oncology & carcinogenesis Original Article Depressant anti‐inflammatory Licking |
| Zdroj: | Animal Models and Experimental Medicine |
| ISSN: | 2576-2095 |
| DOI: | 10.1002/ame2.12037 |
| Popis: | Background The present study covered an assessment of methanolic acetate fractions of Pistia stratiotes, commonly known as water lettuce, for analgesic, anti‐inflammatory, and CNS depressant activities. Methods The methanol acetate fractions were extracted from Pistia stratiotes and administered to the experimental animals as 200 and 400 mg/kg doses to determine the effect on acetic acid‐induced writhing and formalin‐induced licking and biting, for the assessment of analgesic activity. The anti‐inflammatory assay was done using the carrageenan‐induced hind paw edema method, while assessment of CNS depressant activity was done using the open field and hole cross tests. The effects were compared to standard reference drugs. Results At both doses (200 and 400 mg/kg body weight), the methanolic acetate extract of P. stratiotes showed significant analgesic action (P |
| Databáze: | OpenAIRE |
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