Chromosome rearrangement in Leishmania mexicana M379
| Autor: | Françoise Mathieu-Daudé, N. Gajendran, Jean-Claude Dujardin, Simonne De Doncker, David Muthui, Raymond Hamers, Jianhua Liu, Serge Muyldermans, Dominique Le Ray, D. Jacquet |
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| Rok vydání: | 1991 |
| Předmět: |
Recombination
Genetic Genetics biology Leishmania mexicana Restriction Mapping Chromosomal rearrangement DNA Protozoan Molecular cloning biology.organism_classification Molecular biology Chromosome 17 (human) Blotting Southern Restriction map Extrachromosomal DNA Animals Parasitology Cloning Molecular DNA Circular Molecular Biology Chromosome 22 Genomic organization |
| Zdroj: | Molecular and Biochemical Parasitology. 46:53-60 |
| ISSN: | 0166-6851 |
| Popis: | Circular extrachromosomal elements were observed in a variety of Leishmania species. We show here that two lines originating from the same isolate have been found to contain a circular DNA molecule of 26.6 kb and a linear chromosome of about 250 kb, respectively, which share a homology of more than 20 kb. The circular DNA molecule and its related region on the linear chromosome were cloned and their restriction maps compared. This investigation reveals information about chromosome rearrangement in L. mexicana M379. Further examination will enable us to understand the nature of chromosome rearrangement such as circularization or linearization. |
| Databáze: | OpenAIRE |
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