The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
| Autor: | James Jabalee, Cathie Garnis, Fernanda Weber Mello, Saeideh Maleki, Issraa Shoucair |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Stromal cell
neoplasms Context (language use) Review Cell Communication medicine.disease_cause Catalysis Metastasis Inorganic Chemistry lcsh:Chemistry medicine Humans tumor microenvironment Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Tumor microenvironment Chemistry Organic Chemistry Cancer General Medicine medicine.disease Computer Science Applications MicroRNAs Cell Transformation Neoplastic lcsh:Biology (General) lcsh:QD1-999 Drug Resistance Neoplasm Cancer cell Cancer research Cancer-Associated Fibroblasts RNA Long Noncoding Carcinogenesis extracellular vesicles cancer-associated fibroblasts Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 6837, p 6837 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation. |
| Databáze: | OpenAIRE |
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