Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence
| Autor: | Carolina Lage Crespo, Ana-Maria Lennon-Duménil, Paolo Maiuri, Maël Le Berre, Jean-François Rupprecht, Nir S. Gov, Michael Sixt, Mathieu Coppey, Franziska Lautenschlaeger, Raphaël Voituriez, Simon de Beco, Olivier Bénichou, Stefan Wieser, Nicolas Carpi, Matthew Raab, Carl-Philipp Heisenberg, Verena Ruprecht, Hawa Racine Thiam, Matthieu Piel |
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| Přispěvatelé: | Maiuri, P, Rupprecht, Jf, Wieser, S, Ruprecht, V, Benichou, O, Carpi, N, Coppey, M, De Beco, S, Gov, N, Heisenberg, Cp, Crespo, Cl, Lautenschlaeger, F, Le Berre, M, Lennon-Dumenil, Am, Raab, M, Thiam, Hr, Piel, M, Sixt, M, Voituriez, R |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Biochemistry
Genetics and Molecular Biology(all) Cell Regulator Oryzias Cell Polarity Cell migration Optogenetics Biology Actin cytoskeleton Models Biological General Biochemistry Genetics and Molecular Biology Actins Cell Line Coupling (electronics) Mice Inbred C57BL medicine.anatomical_structure Cell Movement Cell polarity Biophysics medicine Animals Humans Actin Cells Cultured Cytoskeleton |
| Popis: | SummaryCell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns. |
| Databáze: | OpenAIRE |
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