Molecular epidemiology of rabies virus strains isolated from wild canids in Northeastern Brazil
| Autor: | Lúcia Montebello, Juliana Galera Castilho, Maria Luisa Carrieri, Lindenberg M. Machado, Marcelo Yoshito Wada, Paulo Eduardo Brandão, Normélia Rangel, Ivanete Kotait, Vania Alves de Carvalho, Pedro Carnieli, Carla Isabel Macedo, Rosangela Cavalcanti de Carvalho |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Genes Viral Rabies Zoology Animals Wild Biology medicine.disease_cause Genetic analysis Virus Dogs Species Specificity Phylogenetics Virology parasitic diseases medicine Animals Rabies transmission Phylogeny Canidae Disease Reservoirs Molecular Epidemiology Molecular epidemiology Phylogenetic tree Rabies virus medicine.disease Antigenic Variation Infectious Diseases Cats Brazil |
| Zdroj: | Virus Research. 120:113-120 |
| ISSN: | 0168-1702 |
| Popis: | Rabies in wild canids in Northeastern Brazil is frequent and has been reported for some time, with episodes of rabies transmission from these animals to humans also reported. In this study, we analyzed the antigenic and genetic profiles of the rabies virus nucleoprotein gene, isolated from 20 samples taken from domestic animals and wild canids located in the Northeastern region of Brazil. All viruses isolated from domestic animals (dogs and cats) belonged to the antigenic variant 2 (AgV2). Among the wild animal samples, only four were AgV2, and nine showed a divergent antigenic profile. Phylogenetic analysis revealed two Brazilian clusters. Cluster 1 (Brazilian domestic carnivore-related strains) showed two subclusters, called 1A and 1B, and cluster 2 (Brazilian wild canid-related strains) also showed two subclusters, called 2A and 2B. The majority of the samples with divergent antigenic strains segregated into subcluster 2A. The intracluster identity of cluster 1 was 95.6% and that of cluster 2, 92.4%. When clusters 1 and 2 were compared, an identity of 88.6% was found. The genetic analysis of wild canid samples performed in this study indicates that there are two distinct rabies cycles among canids in Brazil, one represented by domestic canids and the other by wild canids. This study shows that the virus samples isolated in Northeastern Brazil are region and species-specific. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect