The effect of frusemide, piretanide and bumetanide on cochlear succinic dehydrogenase
| Autor: | S.D. Comis, T.L. Hayward, S.R. Pratt |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Succinic dehydrogenase
medicine.medical_treatment Intraperitoneal injection Guinea Pigs Pharmacology Cellular and Molecular Neuroscience chemistry.chemical_compound Furosemide otorhinolaryngologic diseases medicine Animals Outer hair cells Diuretics Bumetanide Sulfonamides Piretanide Inner hair cells Cochlea Succinate Dehydrogenase medicine.anatomical_structure chemistry Biochemistry Organ of Corti sense organs medicine.drug |
| Zdroj: | Neuropharmacology. 20(4) |
| ISSN: | 0028-3908 |
| Popis: | Three loop diuretics, frusemide, piretanide and bumetanide, were administered to pigmented guinea pigs by intraperitoneal injection and effects upon cochlear succinic dehydrogenase were studied. All three compounds caused a reduction in the succinic dehydrogenase reaction in stria vascularis and in the organ of Corti. Frusemide and piretanide were more effective in inhibiting the succinic dehydrogenase reaction in the outer hair cells, inner hair cells being less affected. This difference was not evident with bumetanide which appeared to affect all hair cells equally. |
| Databáze: | OpenAIRE |
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