Stable phantom materials for ultrasound and optical imaging
| Autor: | Antonio Adilton Oliveira Carneiro, Alessandro Melo Deana, Theo Z. Pavan, Pedro I. B. G. B. Pelissari, Luciana C. Cabrelli |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Polymers FÍSICA MÉDICA 01 natural sciences Imaging phantom 030218 nuclear medicine & medical imaging 010309 optics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Optics 0103 physical sciences Transmittance Humans Radiology Nuclear Medicine and imaging Absorption (electromagnetic radiation) Ultrasonography Radiological and Ultrasound Technology Phantoms Imaging business.industry Scattering Optical Imaging Ultrasound Polyethylene Low-density polyethylene chemistry Attenuation coefficient business Gels Biomedical engineering |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1361-6560 0031-9155 |
| DOI: | 10.1088/1361-6560/62/2/432 |
| Popis: | Phantoms mimicking the specific properties of biological tissues are essential to fully characterize medical devices. Water-based materials are commonly used to manufacture phantoms for ultrasound and optical imaging techniques. However, these materials have disadvantages, such as easy degradation and low temporal stability. In this study, we propose an oil-based new tissue-mimicking material for ultrasound and optical imaging, with the advantage of presenting low temporal degradation. A styrene-ethylene/butylene-styrene (SEBS) copolymer in mineral oil samples was made varying the SEBS concentration between 5%-15%, and low-density polyethylene (LDPE) between 0%-9%. Acoustic properties, such as the speed of sound and the attenuation coefficient, were obtained using frequencies ranging from 1-10 MHz, and were consistent with that of soft tissues. These properties were controlled varying SEBS and LDPE concentration. To characterize the optical properties of the samples, the diffuse reflectance and transmittance were measured. Scattering and absorption coefficients ranging from 400 nm-1200 nm were calculated for each compound. SEBS gels are a translucent material presenting low optical absorption and scattering coefficients in the visible region of the spectrum, but the presence of LDPE increased the turbidity. Adding LDPE increased the absorption and scattering of the phantom materials. Ultrasound and photoacoustic images of a heterogeneous phantom made of LDPE/SEBS containing a spherical inclusion were obtained. Annatto dye was added to the inclusion to enhance the optical absorbance. The results suggest that copolymer gels are promising for ultrasound and optical imaging, making them also potentially useful for photoacoustic imaging. |
| Databáze: | OpenAIRE |
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