Reduced Occipital Cortex Excitability in Amyotrophic Lateral Sclerosis
| Autor: | Halit Fidanci, Ece Türksoy, Bülent Cengiz, Reha Kuruoğlu, Hande Baltacı |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Physiology business.industry Amyotrophic Lateral Sclerosis Motor Cortex Montreal Cognitive Assessment Cognition Sensory system Audiology Neuropsychological Tests medicine.disease medicine.anatomical_structure Phosphene Visual cortex Neurology Physiology (medical) Cortex (anatomy) Cortical Excitability Medicine Humans Neurology (clinical) Occipital Lobe Amyotrophic lateral sclerosis business Motor cortex |
| Zdroj: | Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 39(6) |
| ISSN: | 1537-1603 |
| Popis: | Purpose In addition to motor cortex involvement, sensory abnormalities have been demonstrated in amyotrophic lateral sclerosis (ALS), including structural and metabolic alterations in the occipital cortex. The aim of this study was to examine occipital excitability changes in ALS. Methods Twenty-one patients with ALS and 16 healthy subjects were enrolled into the study. Phosphene experience and phosphene threshold were studied to assess occipital excitability. Cognitive function was evaluated in both groups by means of Montreal Cognitive Assessment and Addenbrooke's Cognitive Examination-Revised visuospatial score tests. Results Phosphene was experienced in 13 (81.3%) healthy subjects and 9 (42.9%) patients with ALS (P = 0.04). The mean phosphene threshold was not significantly different between the two groups. No correlation existed between phosphene threshold and motor cortical excitability parameters, ALS Functional Rating Scale Revised, Montreal Cognitive Assessment, and Addenbrooke's Cognitive Examination-Revised scores. Conclusions Visual cortex is affected, and the occipital excitability is reduced in ALS, without any relation to motor cortical excitability changes, providing another clue suggestive of sensory involvement in ALS. |
| Databáze: | OpenAIRE |
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