Synthetic Gene Networks That Count
| Autor: | David Shi, Ari E. Friedland, Timothy K. Lu, James J. Collins, Xiao Wang, George M. Church |
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| Rok vydání: | 2009 |
| Předmět: |
DNA
Bacterial Arabinose metabolism Transcription Genetic Green Fluorescent Proteins Gene regulatory network Biology Article Recombinases Viral Proteins Synthetic biology Synthetic gene Recombinase Gene Regulatory Networks Regulatory Elements Transcriptional Promoter Regions Genetic Genetics Digital electronics Multidisciplinary Escherichia coli K12 Models Genetic Bacteria business.industry DNA-Directed RNA Polymerases Gene Expression Regulation Bacterial DNA Modular design Arabinose RNA Bacterial Gene Expression Regulation Cascade Protein Biosynthesis RNA Genetic Engineering business Computer hardware Plasmids Transcription Factors |
| Zdroj: | Science. 324:1199-1202 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1172005 |
| Popis: | One, Two, Three Synthetic biologists take much of their inspiration from computing and electrical engineering, attempting to gain programmability in cells using analogous genetic circuits. Friedland et al. (p. 1199 ; see the Perspective by Smolke ) have constructed complementary Escherichia coli synthetic gene networks that keep track of prior molecular events to function as counters. These modular devices count up to three induction events over a range of frequencies and could be extended to higher numbers. Similar devices may find application in multi-event processes of cell biology, bioengineering, and, potentially, therapeutics. |
| Databáze: | OpenAIRE |
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