| Autor: |
Levi A. Garraway, Angela N. Koehler, Lucienne Ronco, Raymond Pagliarini, Douglas S. Daniels, Fallon Lin, Elizabeth K. Culyba, Cheng Zhong, Timothy A. Lewis, Emily C. Hartman, Jean-Philippe Theurillat, Colin W. Garvie, Nicolas Stransky, Marius S. Pop |
| Rok vydání: |
2023 |
| Popis: |
PDF file - 1496K, Figure S1 - control expression and SMM hits representation; luciferase assay with MITF for BRD32048 and luciferase assay using BRD32048 analogs. Figure S2 - SPR data control graphs for TBX21 reference experiment. Figure S3 alternative SPR data for antibody reference; RU signals for additional reference surfaces. Figure S4 - ETV1 silencing validation data at mRNA and protein levels; alternative view of LNCaP signatures overlap; the proliferative effects of BRD32048 in LNCaP cell line and QPCR validation of BRD32048 inhibited targets. Figure S5 - control expression of indicated proteins and control invasion assays; - proliferation of cell lines in the presence of BRD32048. Figure S6 supportive mechanistic evidence such as ETV1-DNA interaction; BRD32048-induced loss of endogenous ETV1 and the effect of BRD32048 on an acetylation-deficient ETV1 mutant. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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