Modelling intracellular fatty acid transport: possible mechanistic role of cytoplasmic fatty acid-binding protein
| Autor: | M. M. Vork, J. F. C. Glatz, G. J. Van Der Vusse |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
Cytoplasm Intracellular translocation Chemistry Binding protein Cell Membrane Fatty Acids Clinical Biochemistry Fatty acid Biological Transport Cell Biology Fatty Acid-Binding Proteins Myelin P2 Protein Models Biological Fatty acid-binding protein Neoplasm Proteins Membrane Biochemistry Solubilization lipids (amino acids peptides and proteins) Carrier Proteins Intracellular |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 57:11-16 |
| ISSN: | 0952-3278 |
| DOI: | 10.1016/s0952-3278(97)90486-5 |
| Popis: | A computer model is presented in which the role of cytoplasmic fatty acid-binding protein (FABP) in the intracellular translocation of fatty acids (FA) from one membrane to an opposite membrane is studied. The model consists of a cubical space, in which FABP and FA are allowed to diffuse at random. The amount of FA released from the donor membrane and reaching an opposite acceptor membrane is calculated in a variety of conditions. The data provided by the various simulations suggest that FABP can play a significant role in intracellular FA transport only if FABP is able to take up FA directly from FA containing membranes and to directly deliver FA to an acceptor membrane, thus preventing the unfavourable thermodynamical situation in which FA must solubilize in an aqueous environment prior to binding to FABP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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