Temporal trends in new exposure to antiepileptic drug monotherapy and suicide-related behavior
| Autor: | Chen Pin Wang, Megan E. Amuan, Mary Jo Pugh, Jeffrey V. Tabares, Craig J. Bryan, Erin P. Finley, Joyce A. Cramer, Andres M. Kanner, Dale Hesdorffer |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Databases Factual Poison control Risk Assessment Cohort Studies International Classification of Diseases medicine Humans Medical prescription Psychiatry Generalized estimating equation Aged Retrospective Studies Veterans Aged 80 and over Epilepsy business.industry Confounding Age Factors Retrospective cohort study United States Suicide United States Department of Veterans Affairs Cohort Anticonvulsants Female Neurology (clinical) business Risk assessment Demography Cohort study |
| Zdroj: | Neurology. 81:1900-1906 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/01.wnl.0000436614.51081.2e |
| Popis: | Objective: Because some recent studies suggest increased risk for suicide-related behavior (SRB; ideation, attempts) among those receiving antiepileptic drugs (AEDs), we examined the temporal relationship between new AED exposure and SRB in a cohort of older veterans. Methods: We used national Veterans Health Administration databases to identify veterans aged ≥65 years who received a new AED prescription in 2004–2006. All instances of SRB were identified using ICD-9-CM codes 1 year before and after the AED exposure (index) date. We also identified comorbid conditions and medication associated with SRB in prior research. We used generalized estimating equations with a logit link to examine the association between new AED exposure and SRB during 30-day intervals during the year before and after the index date, controlling for potential confounders. Results: In this cohort of 90,263 older veterans, the likelihood of SRB the month prior to AED exposure was significantly higher than in other time periods even after adjusting for potential confounders. Although there were 87 SRB events (74 individuals) the year before and 106 SRB events (92 individuals) after, approximately 22% (n = 16) of those also had SRB before the index date. Moreover, the rate of SRB after AED start was gradually reduced over time. Conclusions: The temporal pattern of AED exposure and SRB suggests that, in clinical practice, the peak in SRB is prior to exposure. While speculative, the rate of gradual reduction in SRB thereafter suggests that symptoms may prompt AED prescription. |
| Databáze: | OpenAIRE |
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