Alterations in antioxidant system, mitochondrial biogenesis and autophagy in preeclamptic myometrium
| Autor: | Mikhail Vysokikh, Polina Vishnyakova, M. V. Marey, Z.S. Khodzhaeva, Maria A. Volodina, Nadezhda V. Tarasova, Gennady T. Sukhikh, Natalya E. Kan |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology and Forensic Medicine Preeclampsia Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine medicine Autophagy reproductive and urinary physiology Pregnancy biology Myometrium Regular Article TFAM medicine.disease female genital diseases and pregnancy complications Mitochondria 030104 developmental biology Endocrinology Mitochondrial biogenesis Oxidative stress 030220 oncology & carcinogenesis embryonic structures biology.protein Molecular Medicine VDAC1 |
| Zdroj: | BBA Clinical |
| ISSN: | 2214-6474 |
| Popis: | Preeclampsia is a pregnancy complication which causes significant maternal and fetal morbidity and mortality worldwide. Although intensive research has been performed in the last 40 years, the pathology of preeclampsia is still poorly understood. The present work is a comparative study of the myometrium of women with normal pregnancy, and those with late- and early-onset preeclampsia (n = 10 for each group). We observed significant changes in the levels of antioxidant enzymes, markers of mitochondrial biogenesis and autophagy proteins in preeclamptic myometrium. Levels of superoxide dismutase 1 and catalase were lower in both preeclamptic groups than the control group. In late-onset preeclampsia, expression levels of essential mitochondria-related proteins VDAC1, TFAM, hexokinase 1, PGC-1α and PGC-1β, and autophagy marker LC3A, were significantly elevated. In the myometrium of the early-onset preeclampsia group OPA1 and Bcl-2 were up-regulated compared to those of the control (p Highlights • Increases in VDAC1, TFAM, HK1, PGC-1α and PGC-1β levels in late-onset preeclamptic myometrium • Autophagy marker LC3A level was higher in the late-onset preeclampsia group. • In early-onset preeclamptic myometrium there is an evidence of enhanced mitochondrial fusion. |
| Databáze: | OpenAIRE |
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