Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared**

Autor: Asma Mani, Tao Feng, Albert Gandioso, Robin Vinck, Anna Notaro, Lisa Gourdon, Pierre Burckel, Bruno Saubaméa, Olivier Blacque, Kevin Cariou, Jamel‐Eddine Belgaied, Hui Chao, Gilles Gasser
Přispěvatelé: Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL), ERC, European Project: 681679, H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC),681679,PhotoMedMet(2017)
Rok vydání: 2023
Předmět:
Zdroj: Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2023, ⟨10.1002/anie.202218347⟩
ISSN: 1521-3757
0044-8249
1433-7851
1521-3773
DOI: 10.1002/ange.202218347
Popis: International audience; Five osmium(II) polypyridyl complexes of the general formula [Os(4,7-diphenyl-1,10phenanthroline)2L] 2+ were synthesized as photosensitizers for photodynamic therapy by varying the nature of the ligand L. Thanks to the pronounced π-extended structure of the ligands and the heavy atom effect provided by the osmium center, these complexes exhibit a high absorption in the near-infrared (NIR) region (up to 740 nm), unlike related ruthenium complexes. This led to promising phototoxicity in vitro against cancer cells cultured as 2D cell layers but also in multicellular tumor spheroids upon irradiation at 740 nm. The complex [Os(4,7-diphenyl-1,10-phenanthroline)2(2,2'-bipyridine)] 2+ was found to be the most efficient against various cancer cell lines, with high phototoxicity indexes. Experiments on CT26 tumorbearing BALB/c mice also indicate that the Os(II) complexes could significantly reduce tumor growth under 740 nm laser irradiation. The high phototoxicity in the biological window of this structurally simple complex makes it a promising photosensitizer for cancer treatment.
Databáze: OpenAIRE
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