Disrupted network topology in patients with Lewy bodies dementia compared to Alzheimer's disease, Parkinson disease dementia and Health Control
| Autor: | Hucheng Zhou, Ping Wu, Qihao Guo, Jiehui Jiang, Chuantao Zuo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Lewy Body Disease medicine.medical_specialty China Disease Lewy bodies dementia 03 medical and health sciences 0302 clinical medicine Text mining Alzheimer Disease Internal medicine mental disorders medicine Dementia Humans Pathological Lewy body medicine.diagnostic_test business.industry Order (ring theory) Brain Parkinson Disease medicine.disease 030104 developmental biology Positron emission tomography Case-Control Studies Positron-Emission Tomography Nerve Net business 030217 neurology & neurosurgery |
| Zdroj: | EMBC |
| ISSN: | 2694-0604 |
| Popis: | The clinical manifestation of Lewy body dementia (DLB) is distinct from Alzheimer's disease (AD), but overlap with Parkinson's disease dementia (PDD). However, little is known about different topology properties of abnormal brain networks associated with these neurodegenerative diseases. In order to study the difference of brain networks in various dementia subtypes, we used $^{\mathbf {18}}\text{F}$-Fluorodeoxyglucose positron emission tomography ($^{\mathbf {18}}\text{F}$-FDG PET) images and graph theory methods to investigate altered whole-brain intrinsic glucose metabolic functional networks in three Chinese dementia groups compared to healthy control (HC) group, including 22 AD patients, 18 PDD patients, 22 DLB patients and 22 HC subjects from Huashan Hospital, Shanghai, China. The experimental results disclosed that in the three dementia groups, compared to HC group, the small-world characteristics were lost. Additionally, compared with HC group, the clustering coefficients of three dementia groups were higher; the characteristic path lengths were longer. In terms of local efficiency and global efficiency, it was at the lowest level in DLB group. We also found differences about distributions of hub regions amongst the four groups. This finding could further help physicians to understand pathological mechanisms of different dementia. |
| Databáze: | OpenAIRE |
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